CONGRATULATIONS to Dr. Joseph Henry Steinbach
Dr. Joe Henry Steinbach's Program Project Grant titled "Anesthetics: Cellular and Molecular Actions" has been renewed for 5 years by the National Institute of General Medical Sciences (NIGMS). The project, currently in its 16th year, consists of three Cores and four projects.
The cores are:
The Projects are titled:
The work proposed in this Program is designed to define the molecular target(s) for anesthetic steroids and to clarify the way in which action at these targets results in anesthesia. Each project addresses one or more aspects of the actions of anesthetic steroids at the cellular and molecular level. As a whole, the Program will integrate these complementary studies and provide resources for continued development of novel compounds and for assays of drug effects on behavioral states. Total award amount is $9 million.
CONGRATULATIONS to Richard Hotchkiss, M.D.
Dr. Richard Hotchkiss's Federal Contract with the Defense Threat Reduction Agency (DTRA), funded through the Department of Defense (DoD) has been renewed for a second year. The project titled "Prevention of Apoptosis and Death Due to Biological Agents via Treatments with Anti-Apoptotic Peptides". The project's primary objective is to identify therapeutic molecules that inhibit select agent-induced apoptosis while preserving cell and function and begin to develop those materials for human use. The scope of work proposes to develop an effective therapy for Y.pestis, Ebola virus, B. anthracis, and other bioweapons based upon preventing apoptotic death of immune cells by administration of novel anti-apoptotic compounds. Total award amount for the second year of the contract is $1.78 million.
CONGRATULATIONS to Narasimhan Gautam, Ph.D.
Dr. Narasimhan Gautam received a four year grant award from the National Institute of General Medical Sciences titled "G Protein Subunit Function". The project focuses on the study of the heterotrimeric G proteins that mediate the majority of signaling pathways in mammalian cells. Their receptors are one of the most important targets of therapeutic drugs. Identifying the mechanistic and functional bases of G protein movements between external and internal membranes of cells can provide newer therapeutic sites and targets for diseases caused by aberrant signaling. Total award amount is $1.27 million.
CONGRATULATIONS to Deepak Saini, Ph.D.
Deepak Saini, Ph.D., a Postdoctoral Research Associate in Dr. Narasimhan Gautam's lab, received a two year fellowship award from the American Heart Association Heartland Affiliate. Dr. Saini's research centers on the study of the role of receptor mediated G protein beta gamma complex translocation to different intracellular organelles in signaling. The objective is to identify the biological role of this receptor initiated betagamma translocation.
CONGRATULATIONS to Christopher Lingle, Ph.D.
Dr. Christopher Lingle received 2 grant awards this year. The grant titled "Auxillary Subunits of Ca2+ Activated K+ Channels" has been renewed for four years by the National Institute of General Medical Sciences (NIGMS). The long term aim of this project is to understand the structural components of BK-type Ca2+ - and voltage activated K+ and their functional properties and physiological roles.
This is in addition to his renewal earlier this year titled "Allosteric Regulation of Ion Channel Gating" from NIGMS to study and understand the underlying molecular mechanisms by which naturally occurring stimuli regulate the opening and closing of the BK-type calcium-activated potassium. Award total for both grants is $2.7 million.